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- Title
The underlying cellular mechanism of fibrosis.
- Authors
RODEMANN, H. PETER; BINDER, ANKE; BURGER, ANKE; GÜVEN, NURI; LÖFFLER, HEIDI; BAMBERG, MICHAEL
- Abstract
Fibrosis is a common sequela of various exogenous insults to a variety of parenchymal tissues. The underlying mechanisms of the induction and progression of fibrosis both at the molecular and cellular level have not been clarified so far. In the present study the cellular level have not been clarified so far. In the present study the cellular processes that ultimately may lead to interstitial fibrosis are described using the model of radiation-induced terminal differentiation in the fibroblast/fibrocyte cell system. The data reported herein will provide evidence that exogenously induced changes in the proliferation and differentiation pattern of the fibroblast/fibrocyte cell system based on either autocrine and/or paracrine mediators represent the underlying cellular mechanism of fibrosis. Using co-culture systems of parenchymal cells (fibroblasts and type II pneumocytes), the intercellular communication via cytokines, which may lead to fibrosis have been studied. TGFβ1 could be described as one key modulator of these cellular processes.
- Publication
Kidney International Supplement, 1996, Issue 54, pS-32
- ISSN
0098-6577
- Publication type
Academic Journal