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- Title
Cyanocobalamin/Salcaprozate Sodium: A Novel Way to Treat Vitamin B<sub>12</sub> Deficiency and Anemia.
- Authors
Smith, Lillian; Mosley, Juan; Ford, Megan; Courtney, Jonathan
- Abstract
Background: Vitamin B12 deficiency anemia is a medical condition characterized by a low red blood cell count and vitamin B12. Various treatment options are available for vitamin B12 deficiency. Cyanocobalamin comes in an array of formulations, including injection, nasal spray, powder, solution, sublingual, and tablets. However, many oral formulations are considered supplements, which are not regulated by the US Food and Drug Administration. Objective: The purpose of this review is to compare cyanocobalamin/salcaprozate sodium (SNAC) with other available cyanocobalamin formulations based on pharmacokinetics and efficacy. Discussion: Injections of vitamin B12 typically have been the predominant method for treating patients who require a fast or highly bioavailable response. However, the pharmacokinetic profile of cyanocobalamin/SNAC was shown to be more favorable than that of another oral formulation of cyanocobalamin (not containing SNAC), because it reached a higher peak plasma concentration than the other oral formulation. Conclusion: Cyanocobalamin/SNAC is a major advancement in the treatment of hypocobalaminemia because it is the first formulation to include the absorption promoter SNAC. Cyanocobalamin/ SNAC was shown to be as effective as intramuscular cyanocobalamin in restoring normal levels of serum cobalamin, which makes this drug an attractive option for the treatment of patients with vitamin B12 deficiency.
- Publication
Journal of Hematology Oncology Pharmacy, 2016, Vol 6, Issue 2, p42
- ISSN
2164-1153
- Publication type
Academic Journal