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- Title
Concurrencia de cáncer de mama e infecciones virales: Serie de casos y Revisión bibliográfica.
- Authors
Calderón, Gabriela; Pizarro, Rommy; Pinto-Paz, Mirian; Villegas, Valeria; Castillo, Miluska; Castaneda, Carlos A.
- Abstract
Introduction: Altered immunity associated with malignancy or chemotherapy could predispose to the reactivation of common viruses. Objective: Calculate the prevalence of serum markers of infection and viral reactivation during the chemotherapeutic management of patients with breast cancer who attend to the Instituto Nacional de Enfermedades Neoplásicas (INEN). Methods: A total of 56 patients with breast cancer treated with poly-chemotherapy were evaluated. The blood sample taken for the serological analysis was made during the diagnosis of breast cancer and the prevalence of infection and reactivation by hepatitis A virus (HAV), B (HBV) and C (HCV), Epstein Barr virus (EBV), herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) and Cytomegalovirus (CMV) was evaluated through a series of cases and a bibliographic review. Results: The median age of the patients was 48 years old. Clinical stages II and III were the most frequent (both with 41.1%). 83.9% received neo/adjuvant chemotherapy, 14.3% in metastatic setting and 1.8% observations. The frequency of serology is a previous high infection for all the viruses evaluated (HAV 100%, HBV 28.6%, EBV 100%, HSV-1 92.9%, HSV-2 35.7% and CMV 96.4%). Active infection was found in 6 (10.7%) cases, of which 1.8%, 5.4% and 3.6% corresponded to EBV, HSV-1 and HSV-2, respectively. There was no elevation of transaminases or symptoms due to acute viral symptoms during the use of chemotherapy. Conclusions: There is a high prevalence of viral infections (Hepatitis, Herpes, Epstein-Barr and Cytomegalovirus) in patients with breast cancer treated in the INEN, evaluated before the chemotherapy treatment; however, the risk of developing reactivation is very low.
- Publication
Carcinos, 2018, Vol 8, Issue 1, p19
- ISSN
2222-5730
- Publication type
Academic Journal