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- Title
Study of the effects of ofloxacin (211mg) on the thickness of spermatogenic epithelium pipes in adult male rats and the therapeutic effectiveness of royal jelly.
- Authors
Hessami, Siran; Nejati, Vahid
- Abstract
Objectives: Ofloxacin is an antibiotic of the fluoroquinolone drug class,used for alleviating diseases and infections of theurinary and reproductive systems. Royal jelly is a honey secretion from the hypopharyngeal glands of worker bees. The objective of this study was to investigate the effects of ofloxacin on the thickness of spermatogenic epithelium pipes and determine the therapeutic effectiveness of royal jelly. Materials and Methods: Overall, 22 adult male rats were evaluated in this study. The rats were divided into nine groups (study and control groups). Ofloxacin was administered via gavage in the study group (group 1). During a 14-day cycle, all three groups received 200mg of ofloxacin (0.3 ml). Group 2 was euthanized after a 14-day cycle, whereas group 3 was maintained for another 14 days (28 days) without receiving any medications after the end of the first cycle. Group 4 at the end of the first cycle received 14 days of treatment with royal jelly (28 days). Then, groups 3 and 4 after finishing medication and treatment cycles (28 days) were euthanized, and abdominal and testicular tissues were extracted. Tissue sections were stained with hematoxylin/eosin. Results: The study showed that 211 mg of ofloxacin significantly reduced the thickness of spermatogenic epithelial pipes, compared to the control group. Moreover, royal jelly treatment made relative improvements in rats. Conclusion: Ofloxacin significantly reduced the thickness of spermatogenic epithelial pipes and royal jelly treatment made relative improvements in rats.
- Publication
Avicenna Journal of Phytomedicine, 2015, Vol 5, p53
- ISSN
2228-7930
- Publication type
Academic Journal