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- Title
Effect of short and long-term treatment with sardine (Sardinapilchardus) protein hydrolysates on cholesterol concentration and lipid peroxidation in rats fed a high cholesterol diet.
- Authors
Nora, Athmani; Amine, Allaoui; Moncef, Nasri; Ahmed, Boualga
- Abstract
Hypercholesterolemia is a major risk factor of cardiovascular diseases (CVD). A limited number of experimental studies have shown that sardine protein hydrolysates (SPH) could be a very useful natural compound to prevent hypercholesterolemia by both improving the lipoprotein profile and modulating oxidative stress. In the present study, the effect of short and long term treatments with SPH were examined on serum lipid contents, lipid peroxidation and antioxidant enzymes activities in rats fed cholesterol-enriched diet. At day 0, rats were divided into five groups. The group of day 0 was the standard group, and the four remaining groups were divided into two parts of two groups each consuming for 14 or 28 days an hypercholesterolemic diet, and treated (HC-SPH) or not (HC) by gavage with SPH. Compared with day 0, serum TC contents were increased at day 14 and remained unchanged at day 28 in HC-SPH group. These values were decreased in HC-SPH versus HC. Liver and heart TBARS concentrations were increased at day 14 then diminished at day 28 in HC-SPH group. Liver and heart SOD and CAT activities were decreased at short term then remained unchanged at long term in HC-SPH group. In addition, these activities were enhanced in HC-SPH versus HC. In conclusion, these results indicate the potential effects of short and long term treatments of SPH to improved cholesterolemia and reduced radical attack in rats fed high-cholesterol diets.
- Publication
South Asian Journal of Experimental Biology, 2021, Vol 11, Issue 6, p733
- ISSN
2230-9799
- Publication type
Academic Journal
- DOI
10.38150/sajeb.11(6).p733-745