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- Title
Benzimidazole scaffold as a versatile biophore in drug discovery: A review.
- Authors
Prajapat, Prakash; Kumawat, Monika; Talesara, Ganpat L.; Kalal, Priyanka; Agarwal, Shikha; Kapoor, Chandra Shekhar
- Abstract
Heterocyclic molecules are pervasive in several areas of life sciences. These molecules perform numerous significant functions in nature, medicine, and technology. Nitrogen-containing heterocycles specially azoles family are the subject of continuous interest in organic synthesis owing to the fact that they occur ubiquitously in pharmacologically active natural products, multipurpose oriented functional materials as well as highly potent pharmaceuticals and agrochemicals. Benzimidazole has been a popular heterocycle in medicinal and pharmaceutical chemistry allowing the construction of structurally different molecules with diverse bioactivities viz. anticancer, anti-inflammatory, antimicrobial, antimalarial, anticonvulsant, antiviral, analgesic, antiparasitic etc. This review article is an effort to compile the literature of several synthetic approaches and bio-evaluation of benzimidazole analogues. This review helps in the further development of novel benzimidazoles for future drug discovery.
- Publication
Chemistry & Biology Interface, 2018, Vol 8, Issue 1, p1
- ISSN
2249-4820
- Publication type
Academic Journal