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- Title
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW 1,3,4-THIADIAZOLE DERIVATIVES FOR THEIR ANTIMICROBIAL ACTIVITIES.
- Authors
Raj, Mahendrasinh M.; Patel, Hemul V.; Raj, Lata M.; Patel, Naynika K.
- Abstract
In the present study, novel Thiadiazoles were synthesized by reaction of benzoic and 2-hydroxybenzoic acid with thiosemicarbazide to synthesize 5-phenyl-1,3,4-thiadiazol-2-amine(A) and 2-(5-amino-1,3,4-thiadiazole-2-yl) phenol(B).From these compounds various derivatives of 1,3,4-Thiadiazole derivatives (A1-A4 and B1-B4) have been synthesized. The chemical structures of the synthesized compounds were confirmed by means of IR, ¹H NMR, and nitrogen estimation. These compounds were screened for antibacterial (Staphylococcus aureus ATCC 9144, Becillus Cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853 and anti-fungal (Aspergillus niger ATCC 9029 and Aspergillus fumigatus ATCC 46645) by paper disc diffusion technique.
- Publication
International Journal of Pharmaceutical, Chemical & Biological Sciences, 2013, Vol 3, Issue 3, p814
- ISSN
2249-9504
- Publication type
Academic Journal