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- Title
CUBOSOMES-A DRUG DELIVERY SYSTEM.
- Authors
Tilekar, Komal; Khade, Prashant; Kakade, Sujit; Kotwal, Sachin; Patil, Ravindra
- Abstract
Cubosomes are the square and rounded particles with internal cubic lattices visible. The discovery of cubosomes is a unique story and spans the fields of food science, differential geometry, biological membranes, and digestive processes. Cubosomes are self-assembled nanostructured particles formed by aqueous lipid and surfactant systems. Cubosomes are thermodynamically stable; they have a structure like "honeycombed" with bicontinuous domains of water and lipid in which surfactant assembles into bilayers and twisted into a three dimension, periodic, and minimal surface, forming a tightly packed structure. They exhibit different internal cubic structure and composition with different drug-loading modalities. Overall, cubosome have great potential in drug nano formulations for melanoma therapy owing to their potential advantages, including high drug payloads due to high internal surface area and cubic crystalline structures, relatively simple preparation method, biodegradability of lipids, the ability of encapsulating hydrophobic, hydrophilic and amphiphilic substances, targeting and controlled release of bioactiveagents. Cubosome dispersions are bioadhesive and biocompatible. Because of their properties, cubosome are versatile systems, administrable by different ways such as orally, percutaneously and parenterally. Cubosome structure by means of electron microscopy, "lightscattering", x-ray and "NMR", nevertheless few researchers have been studying the potential of cubosome as "delivery systems". Hydrating a surfactant or polar lipid that forms cubic phase and then dispersing a solid like phase into smaller particles usually forms a cubosomes. Such novel particles are utilized to encapsulate guest molecules which are either hydrophilic, lipophilic oramphiphilic, due to the compartmentalization of its structure.
- Publication
International Journal of Pharmaceutical, Chemical & Biological Sciences, 2014, Vol 4, Issue 4, p812
- ISSN
2249-9504
- Publication type
Academic Journal