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- Title
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL BROMO-PYRIMIDINE ANALOGS AS ANTICANCER AND ANTIMICROBIAL AGENTS.
- Authors
Kumar, G. V. Suresh; Sridhar, K. A.
- Abstract
A novel series of 5-bromo-pyrimidine derivatives (3,4,5a-l and 6a-h) were synthesized through multi step reactions starting from 5-bromo-2,4-dichloro pyrimidine. The newly synthesized compounds were characterized using elemental analysis and spectral data (IR, 1H NMR, 13C NMR and LC-MS) analysis. The titled compounds were evaluated for antimicrobial activity by broth dilution method and their in vitro cytotoxic activity. Among the synthesized compounds 5a, 5c, 5e, 6b, 6d, and 6h exhibit broad spectrum antimicrobial activity against tested microbial strains. The invitro cancer results ascertain 5c, 5e, 6d, 6g and 6h are most potent molecules in comparison to reference standard Dasatinib.
- Publication
International Journal of Pharmaceutical, Chemical & Biological Sciences, 2019, Vol 9, Issue 1, p27
- ISSN
2249-9504
- Publication type
Academic Journal