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- Title
Comparative study of mild versus moderate to severe thrombocytopenia in third trimester of pregnancy in a tertiary care hospital.
- Authors
Vyas, Rupa; Shah, Sapana; Yadav, Pushpa; Patel, Ushma
- Abstract
Aims & objectives: To determine etiology, maternal complications and fetomaternal outcome in third trimester of pregnancies complicated by moderate to severe thrombocytopenia and compare it with mild thrombocytopenia. Materials & methods: It was a case control cross sectional study of third trimester pregnancy with thrombocytopenia. Platelet count of 1,00,000 to 1,50,000/μL, 50,000 to 1,00,000/μL & <50,000/μL were classified as mild, moderate and severe thrombocytopenia respectively. Etiology and fetomaternal outcome of thrombocytopenia in third trimester of pregnancy were evaluated and compared. Results: Among 4818 deliveries, 378 women (7.67%) had thrombocytopenia. Out of them 112 (2.3%) women had moderate to severe thrombocytopenia (study group) and 266 had mild thrombocytopenia (control group). Major causes were gestational thrombocytopenia (GT), idiopathic thrombocytopenic purpura (ITP), preeclampsia, HELLP syndrome, malaria, dengue and other etiologies of viremia. Maternal complications due to bleeding tendencies like placental abruption, postpartum hemorrhage were evident in the study population (p< 0.001). Fetal complications were significantly higher in study group. Early neonatal thrombocytopenia depended on etiology rather than severity of maternal thrombocytopenia. Conclusions: Outcome of pregnancy with moderate to severe thrombocytopenia depends mainly on the primary disease causing thrombocytopenia. Adverse outcomes are especially seen with pregnancy complicated by preeclampsia and HELLP syndrome. Fetomaternal outcome is favorable in ITP and gestational thrombocytopenia. Early detection and intervention play a key role in decreasing fetomaternal morbidities.
- Publication
NHL Journal of Medical Sciences, 2014, Vol 3, Issue 1, p8
- ISSN
2319-2283
- Publication type
Academic Journal